Issues for Surgery |
For treatment of angina – exacerbation of symptoms if omitted. Risk of QT-interval prolongation if continued (see Interaction(s) with Common Anaesthetic Agents and Interaction(s) with other Common Medicines used in the Perioperative Period). |
Advice in the Perioperative period |
Elective and Emergency Surgery Continue. Post-operative Advice Restart post-operatively as soon as next dose is due. |
Interaction(s) with Common Anaesthetic Agents |
QT-Interval prolongation (see also Interaction(s) with other Common Medicines used in the Perioperative Period) Anaesthetic agents that may be used in the perioperative period that are known to, or predicted to, prolong the QT-interval include1, 2: -
* monitor ECG with concurrent use if risk factors for QT-prolongation are also present (increasing age, female sex, cardiac disease, and some metabolic disturbances e.g. hypokalaemia) |
Interaction(s) with other Common Medicines used in the Perioperative Period |
QT-Interval Prolongation Ranolazine prolongs the QT-interval in a dose-dependent manner3. Concurrent use with other drugs that can prolong the QT-interval might increase the risk. These include1, 2, 3, 4: -
*monitor ECG with concurrent use if risk factors for QT-interval prolongation also present (increasing age, female sex, cardiac disease, and some metabolic disturbances e.g. hypokalaemia) Hypokalaemia Corticosteroids may cause hypokalaemia, potentially increasing the risk of torsades de pointes – monitor serum potassium concentrations1. |
Further Information |
None relevant.
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References |
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