Issues for Surgery
For treatment of angina – exacerbation of symptoms if omitted.
Advice in the Perioperative period
Elective and Emergency Surgery
Restart post-operatively as soon as next dose is due.
Interaction(s) with Common Anaesthetic Agents
None1, 2, 3, 4.
Interaction(s) with other Common Medicines used in the Perioperative Period
Ranolazine prolongs the QT-interval in a dose-dependent manner3. Concurrent use with other drugs that can prolong the QT-interval might increase the risk. These include1, 2, 3, 4: -
*monitor ECG with concurrent use if risk factors for QT-interval prolongation also present (increasing age, female sex, cardiac disease, and some metabolic disturbances e.g. hypokalaemia)
Corticosteroids may cause hypokalaemia, potentially increasing the risk of torsades de pointes – monitor serum potassium concentrations1.