Issues for Surgery |
Recurrence of vascular headache, classical migraine, common migraine, or cluster headache if omitted. Risk of withdrawal symptoms if omitted (see Further Information). |
Advice in the Perioperative period |
Elective and Emergency Surgery Continue. Post-operative Advice Restart post-operatively when dose next due. |
Interaction(s) with Common Anaesthetic Agents |
CNS Depression see also Interaction(s) with other Common Medicines used in the Perioperative Period Pizotifen has CNS depressant effects which may be additive with other medicines that also have CNS depressant effects such as 1, 2, 3: -
(Consult British National Formulary for available drugs in each class) |
Interaction(s) with other Common Medicines used in the Perioperative Period |
CNS Depression see also Interaction(s) with Common Anaesthetic Agents Sedating antihistamines have CNS depressant effects which may be additive with other medicines that also have CNS depressant effects such as 1, 2, 3: -
(Consult British National Formulary for available drugs in each class) Seizure threshold Pizotifen may lower the seizure threshold; concurrent use with other drugs that lower the seizure threshold (e.g. tramadol) might result in additive effects 3. |
Further Information |
Withdrawal Acute withdrawal reactions including anxiety, tremors, insomnia, nausea, and loss of consciousness have been reported following abrupt cessation of pizotifen therefore gradual withdrawal is recommended 2. |
References |
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