Memantine


  Issues for Surgery


Deterioration in cognitive function if omitted.


  Advice in the Perioperative period


Elective and Emergency Surgery

Continue.


  Interaction(s) with Common Anaesthetic Agents


Esketamine and Ketamine

Concurrent use of memantine and esketamine / ketamine should be avoided. Both medicines are N-methyl-D-aspartate (NMDA) antagonists and potentially concurrent use could increase the frequency and severity of central nervous system adverse drug reactions including psychosis1, 2, 3.


  Interaction(s) with other Common Medicines used in the Perioperative Period


None1, 2, 3.


  Further Information

 

None relevant.


  References


  1. Joint Formulary Committee. British National Formulary (online) London: BMJ Group and Pharmaceutical Press. http://www.medicinescomplete.com [Accessed on 10th May 2019]
  2. Summary of Product Characteristics – Ebixa® (memantine). Lundbeck limited. Accessed via www.medicines.org.uk 10/05/2019 [date of revision of the text October 2016]
  3. Baxter K, Preston CL (eds), Stockley’s Drug Interactions (online) London: Pharmaceutical Press. http://www.medicinescomplete.com [Accessed on 10th May 2019]