Issues for Surgery
Exacerbation of irritable bowel syndrome and constipation if omitted.
Advice in the Perioperative period
Elective and Emergency Surgery
Consider checking U&E’s pre-operatively if patient reports severe diarrhoea.
Review if patient develops reduced gastrointestinal motility (e.g. ileus) post-operatively1, 2.
Patients undergoing Colorectal Surgery
Interaction(s) with Common Anaesthetic Agents
None1, 2, 3.
Interaction(s) with other Common Medicines used in the Perioperative Period
No pharmacokinetic interactions are anticipated1, 2; however, concurrent use of Non-Steroidal Anti-inflammatory drugs (NSAIDs) or proton pump inhibitors (PPIs) with linaclotide may increase the risk of diarrhoea2, 3. Caution is advised in patients who are also prescribed oral medications with a narrow therapeutic range as absorption may be affected2.