Ezetimibe

  Issues for Surgery

Potential increased absorption of dietary cholesterol if omitted.

Combination product containing simvastatin – increased risk of myocardial infarction if omitted (see Statins monograph).

Combination product containing simvastatin – risk of myopathy and rhabdomyolysis if continued (see Statins monograph).

  Advice in the Perioperative period

Elective and Emergency Surgery

Continue – including the following combination product: -

• Inegy^® (ezetimibe + simvastatin) – see also Statins monograph

Post-operative Advice

Restart post-operatively as soon as next dose is due.

  Interaction(s) with Common Anaesthetic Agents

None^{1, 2, 3, 4}.

  Interaction(s) with other Common Medicines used in the Perioperative Period

None^{1, 2, 3, 4}.

  Further Information

None relevant.

  References

1. Joint Formulary Committee. British National Formulary (online) London: BMJ Group and Pharmaceutical Press. http://www.medicinescomplete.com [Accessed on 18^th July 2019]
2. Summary of Product Characteristics – Ezetrol^® (ezetimibe) 10mg Tablets. Merck Sharp and Dohme Limited. Accessed via www.medicines.org.uk 18/07/2019 [date of revision of the text February 2018]
3. Baxter K, Preston CL (eds), Stockley’s Drug Interactions (online) London: Pharmaceutical Press. http://www.medicinescomplete.com  [Accessed on 18^th July 2019]
4. Ezetimibe. In: Brayfield A (Ed), Martindale: The Complete Drug Reference. London: The Royal Pharmaceutical Society of Great Britain. Electronic version. Truven Health Analytics, Greenwood Village, Colorado, USA. Available at: http://www.micromedexsolutions.com. [Accessed 18^th July 2019]