Issues for Surgery |
For vestibular disorders – exacerbation of symptoms (e.g. vertigo, tinnitus, nausea and vomiting in Ménière’s disease) if omitted. |
Advice in the Perioperative period |
Elective and Emergency Surgery Continue – including the following combination product:
Post-operative Advice If taken regularly, restart post-operatively as soon as next dose is due, otherwise restart when required. |
Interaction(s) with Common Anaesthetic Agents |
CNS Depression see also Interaction(s) with other Common Medicines used in the Perioperative Period Sedating antihistamines have CNS depressant effects which may be additive with other medicines that also have CNS depressant effects such as 1, 2, 3:-
(Consult British National Formulary for available drugs in each class) For combination product containing dimenhydrinate The antimuscarinic action of dimenhydrinate may be additive with agents that also have antimuscarinic effects such as atropine and glycopyrronium 1. |
Interaction(s) with other Common Medicines used in the Perioperative Period |
CNS Depression see also Interaction(s) with Common Anaesthetic Agents Sedating antihistamines have CNS depressant effects which may be additive with other medicines that also have CNS depressant effects such as 1, 2, 3: -
(Consult British National Formulary for available drugs in each class) Seizure threshold Cinnarizine may lower the seizure threshold; concurrent use with other drugs that lower the seizure threshold (e.g. tramadol) might result in additive effects 3. For combination product containing dimenhydrinate Antiemetics Nefopam |
Further Information |
None relevant. |
References |
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