Betahistine


   Issues for Surgery 



Exacerbation of symptoms associated with Ménière’s disease (e.g. vertigo, tinnitus and hearing loss) if omitted.


  Advice in the Perioperative period 


Elective and Emergency Surgery

Continue.


Post-operative Advice

Restart post-operatively when next dose due.


  Interaction(s) with Common Anaesthetic Agents 


None 1, 2, 3.


   Interaction(s) with other Common Medicines used in the Perioperative Period 


Antiemetics

Betahistine is a histamine analogue; theoretically concurrent administration of betahistine with H1 receptor antagonists (e.g. cyclizine) may result in mutual attenuation of effect1, 2, however, there is only one isolated, unconfirmed case report3. Bear the interaction in mind in case of an unexpected response to treatment.


   Further Information 


Nil relevant.


  References  


  1. Joint Formulary Committee. British National Formulary (online) London: BMJ Group and Pharmaceutical Press. http://www.medicinescomplete.com [Accessed on 4th March 2021]
  2. Summary of Product Characteristics – Betahistine 16mg tablets. Aurobindo Pharma – Milpharm Ltd. Accessed via www.medicines.org.uk 04/03/2021 [date of revision of the text September 2020]
  3. Baxter K, Preston CL (eds), Stockley’s Drug Interactions (online) London: Pharmaceutical Press. http://www.medicinescomplete.com [Accessed on 4th March 2021]