Issues for Surgery
Exacerbation of symptoms associated with Ménière’s disease (e.g. vertigo, tinnitus and hearing loss) if omitted.
Advice in the Perioperative period
Elective and Emergency Surgery
Restart post-operatively when next dose due.
Interaction(s) with Common Anaesthetic Agents
None 1, 2, 3.
Interaction(s) with other Common Medicines used in the Perioperative Period
Betahistine is a histamine analogue; theoretically concurrent administration of betahistine with H1 receptor antagonists (e.g. cyclizine) may result in mutual attenuation of effect1, 2, however, there is only one isolated, unconfirmed case report3. Bear the interaction in mind in case of an unexpected response to treatment.