Antispasmodics (Smooth Muscle Relaxants)

Alverine citrate, Mebeverine, Peppermint oil

  Issues for Surgery

For irritable bowel syndrome, smooth muscle spasm, dysmenorrhoea – loss of symptomatic relief if omitted.

  Advice in the Perioperative period

Elective and Emergency Surgery
Continue.

EXCEPT: -

• Fybogel mebeverine® (ispaghula + mebeverine) – see Bulk-forming Laxatives monograph.

Post-operative Advice
Resume post-operatively, if needed, once enteral intake resumed.

Review alverine citrate and mebeverine if patient develops reduced gastrointestinal motility (e.g. ileus) post-operatively^{1, 2}.

  Interaction(s) with Common Anaesthetic Agents

None^{1, 2, 3, 4, 5}.

  Interaction(s) with other Common Medicines used in the Perioperative Period

None^{1, 2, 3, 4, 5}.

  Further Information

None relevant.

  References

1. Joint Formulary Committee. British National Formulary (online) London: BMJ Group and Pharmaceutical Press. http://www.medicinescomplete.com [Accessed on 7^th March 2021]
2. Summary of Product Characteristics – Spasmonal® (alverine citrate) 60mg Hard Capsules. Mylan. Accessed via www.medicines.org.uk 07/03/2021 [date of revision of the text February 2018]
3. Summary of Product Characteristics – Mebeverine 135mg film-coated tablets. Aurobindo Pharma-Milpharm Ltd. Accessed via www.medicines.org.uk 07/03/2021 [date of revision of the text October 2020]
4. Summary of Product Characteristics – Colpermin® (peppermint oil) IBS Relief Capsules. McNeil Products Ltd. Accessed via www.medicines.org.uk 07/03/2021 [date of revision of the text October 2020]
5. Baxter K, Preston CL (eds), Stockley’s Drug Interactions (online) London: Pharmaceutical Press.