Antispasmodics (Smooth Muscle Relaxants)

Alverine citrate, Mebeverine, Peppermint oil

  Issues for Surgery

For irritable bowel syndrome, smooth muscle spasm, adult enuresis or hyperhidrosis – loss of symptomatic relief if omitted.

  Advice in the Perioperative period

Elective and Emergency Surgery


  • Fybogel mebeverine® (ispaghula + mebeverine) – see Bulk-forming Laxatives monograph.

Post-operative Advice
Resume post-operatively, if needed, once enteral intake resumed.

Review alverine citrate and mebeverine if patient develops reduced gastrointestinal motility (e.g. ileus) post-operatively1, 2.

  Interaction(s) with Common Anaesthetic Agents

None1, 2, 3, 4, 5.

  Interaction(s) with other Common Medicines used in the Perioperative Period

None1, 2, 3, 4, 5.

  Further Information

None relevant.



  1. Joint Formulary Committee. British National Formulary (online) London: BMJ Group and Pharmaceutical Press. [Accessed on 7th March 2021]
  2. Summary of Product Characteristics – Spasmonal® (alverine citrate) 60mg Hard Capsules. Mylan. Accessed via 07/03/2021 [date of revision of the text February 2018]
  3. Summary of Product Characteristics – Mebeverine 135mg film-coated tablets. Aurobindo Pharma-Milpharm Ltd. Accessed via 07/03/2021 [date of revision of the text October 2020]
  4. Summary of Product Characteristics – Colpermin® (peppermint oil) IBS Relief Capsules. McNeil Products Ltd. Accessed via 07/03/2021 [date of revision of the text October 2020]
  5. Baxter K, Preston CL (eds), Stockley’s Drug Interactions (online) London: Pharmaceutical Press.