Dutasteride, Finasteride |
Issues for Surgery |
For benign prostatic hyperplasia – risk of acute urinary retention if omitted. Combination products containing tamsulosin – risk of hypotension if continued (see Alpha-adrenoceptor Blockers monograph). Combination products containing tamsulosin – risk of Intraoperative Floppy Iris Syndrome (IFIS) if continued prior to cataract surgery (see Alpha-adrenoceptor Blockers monograph). |
Advice in the Perioperative period |
Elective and Emergency Surgery Continue – including the following combination product:
Patients undergoing Cataract Surgery
Patients undergoing Transurethral Resection of Prostate (TURP) |
Interaction(s) with Common Anaesthetic Agents |
None for 5-α reductase inhibitors alone1, 2, 3, 4. Hypotension For combination products containing tamsulosin see Alpha-adrenoceptor Blockers monograph. |
Interaction(s) with other Common Medicines used in the Perioperative Period |
Macrolides Antibiotics Clarithromycin and erythromycin are predicted to increase the exposure to dutasteride1, 4. Whilst single surgical prophylactic doses should not pose a problem, monitor for an increase in dutasteride side effects if a prolonged course is required. |
Further Information |
Administration During normal handling the coating on finasteride tablets and the intact dutasteride capsule prevent contact with the active ingredient. However, crushed or broken finasteride tablets and leaking dutasteride capsules should not be handled by women who may be pregnant as transdermal absorption would pose a risk to a male foetus2, 3. Intraoperative Floppy Iris Syndrome (IFIS) For combination products containing tamsulosin see Alpha-adrenoceptor Blockers monograph. |
References |
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